Bead Resuspension / Constant Suspension
Get the same number of beads every time
The use of beads in the life science industry has many benefits. Beads are available in a variety of materials, size, and color. However, there is a constraint to their use, where after a very short period of time the bead suspension often becomes non-uniform (e.g., partitions, settles,or floats depending on density). Current techniques to address the dispensing of this non-uniform suspension can be problematic, and can be extremely difficult in small reaction volumes. The result is often sample-to-sample variations of bead numbers. This is especially deleterious if the beads are clumped, which often occurs during washing and/or separating processes.
This problem may be compounded when beads are used in automated robot screening
cells. The non-contact AFA process is able to keep beads (even Yttrium based
SPA beads) in a uniform suspension without microclumps being present (as is
often the case).
The Covaris products are ideally suited to constant or intermittent mixing, depending on your needs.
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