Overview
The Covaris C-series instruments are designed specifically for the rigorous, demanding and advanced needs of high-throughput environments.
Benefits include:
- Non-contact samples can remain closed. No decapping is necessary
- Highly efficient, poorly soluble compounds are quickly dissolved within seconds
- Automation friendly high-speed process designed with integration capability
Application Areas
Primary Dissolution. The first step in the compound management process is to dissolve a solid in a volume of solvent. Compounds range in solubility from poorly to highly soluble. The AFA™ process has been tested extensively against a range of compounds including glues, gums, glasses, and powders. Results have shown the AFA process to be highly efficient and far superior to conventional techniques, and much quicker.
Compound Re-dissolution. Target compounds undergoing repeated freeze-thaw cycles are susceptible to precipitation. Until now it was very difficult to re-dissolve these solutes. The AFA process is ideally suited to the re-dissolution of these compounds quickly and efficiently.
Solvent Thawing. The majority of compound stores worldwide utilize DMSO as the primary solvent. As DMSO has a freezing point of 18 degrees C, thawing samples is a particular bottleneck requiring whole plates to be thawed to gain access to a small number of samples. The AFA process is unique in that it enables users the capability to thaw a single well of a plate. A number of benefits are derived from this including:
- Integrity. Compounds can be protected from multiple freeze-thaw cycles, reducing the precipitation risk
- Solubility. Reduced freeze-thaw cycles, reduces the precipitation risk
- Speed. A single well can be thawed in as little as 10 seconds
Model C-2000
The Model C-2000 is designed for a high-throughput mixing and thawing applications; however, the system may also be using in cell or tissue homogenization environments. As modular platform system, it can be configured to specific needs using some of the available options below.
| Design Environment |
Options |
- 384 standard 4ml vials (4 racks of 96 vials)
- 1,536 2D bar-coded tubes (16 racks of 96 tube multiwell plates)
- Microplate blocks of both 96 and 384 wells
- Other configurations available
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- Three-axis robot for pick-and-place operations with vials, tubes and plates
- Three-axis robot for AFA transducer movement
- Vision inspection system for auto recognition of rack and deck layout
- Tube and vial drying station to remove residual water from the processed sample
- Temporary seal station for open tube or open plate mixing
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Specifications
| Hardware |
Software |
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The benchtop unit is available in 1.4m and 0.8m length bed sizes with 60cm depth and 60cm height. The unit requires a recirculating chiller.
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The user-friendly, flexible software runs on Windows® XP. Plate scheduling tasks are enabled as well as individually addressable treatment conditions derived from a user generated work list.
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