Primary dissolution of compounds, thawing, and resolution of precipitated compounds is a use of AFA that is gaining wide acceptance in the compound management community.

Current dissolution technologies are either inadequate or have significant drawbacks compared to AFA. This is illustrated in the table below:

Feature	Benefit	Technique
		AFA	Vortex	Sonication
Isothermal	No compound degradation	Yes	Yes	No
Non-contact	Decapping not necessary Washing of instrument not necessary No instrument or compound cross contamination	Yes	Yes	No
Controllable Mechanical Energy	Fast & highly efficient Capable of gum / glue / "glass" dissolution Fast	Yes	No	No/Yes
Automation friendly	Easy integration	Yes	No	No
No consumable	Reduced cost	Yes	Yes	No
Capable of thawing individual wells (3s for a 2D tube)	Reduced freeze thaw cycle for plates	Yes	No	No
Plate / tube independent	Flexible	Yes	No	No

To date a large amount of data has been generated on the application of AFA in compound dissolution. We have included a video to illustrate this; however data is also presented below in comparison to a microplate Sonicator. The data was analyzed using quantitative liquid chromatography.

Clozapine dissolution carried out in a polypropylene 96 well Plate in DMSO