Overview
The Covaris E-series are advanced instruments based on technologies developed from both medical diagnostic imaging and therapeutic ultrasound industries. The E-series automate the Covaris sample preparation processes for high-throughput applications.
Benefits include:
- Cost effective. Higher precision allows fewer repeats, and fewer replicate samples
- Safe. Non-contact, sealed vessel process is ideal for highly infectious and/or small sample processing
- Versatile. Disruption, extraction and dissolution may be improved
Application Areas
Disruption. Many of the current first step processes are manual and uncontrolled. For example, in ADME/Tox the small drug molecule tissue distribution is unknown, therefore, variations may be unknowingly carried through to analysis. In many instances, with the high-speed, iterative Covaris processes, recoveries are higher and precision is improved.
Extraction. Once a cell or tissue matrix is disrupted, it is very difficult to effectively and reproducibly extract desired target molecules. With the Covaris technology, both the time and temperature of a process are controlled. For example, in metabolite applications recoveries are increased, samples are processed in less time, and sample temperature may be maintained isothermal during the "mechanical reflux" process.
Dissolution. Compound screening requires complete dissolution. The Covaris process is highly beneficial for ensuring difficult solutes in small volumes are efficiently dissolved, such as those lyophilized in DMSO.
Non-contact Mixing. Reaction volumes can be mixed and pellets resuspended in milliseconds. Sample integrity is also maintained as the process is non-contact, closed vessel -- no evaporation, no probe, no contact.
What They Do
Although sample preparation requirements are diverse, for most samples, the following ranges apply:
| |
Volume |
Mass |
|
Model E110
|
100-1,000 µl
|
<100 mg
| |
Model E210
|
1,000-10,000 µl
|
<1,000 mg
|
| Covaris Process Features |
- Non-contact, closed vessel
- Rapid, scalable energy
- Isothermal process
- Real-time sample monitoring
- Multiple solvents (aqueous, organic)
|
The E-series instruments may easily be configured for tubes, vials, and micro-well plates, for batch and single sample processing.
Our proprietary software, SonoLab™, runs on Windows® XP with easy-to-use-tools. Create run-time configurations and save for repeat. Save data in a *.csv file format.
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