Genomics
In recent years, the advent of new research areas and technologies such as, epigenetics and "next generation sequencing" has revolutionized the world of sequencing and biology. There is great interest in isolating and analyzing small RNAs, gene regulation, and DNA sequencing across diverse scientific disciplines including microbiology, evolution, ecology, forensics, epidemiology, comparative genomics, and diagnostic applications. This research includes whole genome sequencing, targeted resequencing, analysis of chromatin binding sites along the entire genome by ChIP analysis, methylation analysis, transcriptome analysis, metagenomic surveys, and retrospective studies with archived DNA.
Sample preparation is a critical step in all these analytical techniques. DNA, RNA, and Chromatin sample preparation is one of the most important aspects of optimization of the quality and quantity of nucleic acid material. The exquisite sensitivity of technologies like next-gen sequencing places new demands on the quality of the sample preparation process.
The precise process control of Covaris' AFA™ technology results in nucleic acid samples that are of the utmost quality for all your Genomics applications. AFA enables higher recoveries for nucleic acid extraction, tissue homogenization, chromatin shearing, protein digestion, and cell lysis. It also is isothermal and non-contact, which ensures molecular stability.
Applications for Genomics include:
- Controlled DNA shearing for next generation sequencing and library constructions.
- RNA Extraction from various biological fluids and tissues, especially difficult tissues, such as skin, bones, corneal, museal, seeds, leaves, etc.
- Controlled chromatin shearing for ChIP Analysis for evaluating in vivo interaction of proteins with specific genomic DNA regions.
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