Enlarge image

Covaris systems may be configured in many formats; the following is illustrative only. Please contact Covaris directly for specific questions.

Step 1: If your starting biological material is hard to process tissues, such as bone, muscle, skin, cornea, seed, leaf, please select CryoPrep for effective tissue disruption and homogenization. For softer tissues, such as liver, brain, or cell culture and biological samples in solution, there's no need to use CryoPrep, proceed to step 2.

Step 2: If sample processing temperature needs to be below -20°C for labile target molecules, please select Covaris S-series.

Step 3: If sample preparation temperature can go above 4°C, please select Covaris S-series for single tube processing, or select E-series or L-series for high throughput processing.

If DNA shearing is your primary application, the S2 is the instrument of choice.

	Pre-treatment	Covaris Adaptive Focused Acoustic Products
Product	CryoPrep™	S-series	E-series	L-series
Product Picture
Key feature/ differences	Freeze-fracture pulverization instrument	Single tube	Multiple tubes, serial processing (up to 96 tubes) Or 96-well plate	96- to 1536-well plates Parallel processing
Robotic Integration	No	Yes (custom)	Yes (E210R)	Yes
Typical applications	Hard tissue pulverization	Tissue disruption, homogenization RNA Extraction Cell Lysis Compound dissolution Compound formulation DNA Shearing (Covaris S2) ADME/Tox	Cell Lysis Compound dissolution Compound formulation High-throughput chemistry DNA Shearing (Covaris E210)	Compound dissolution Reaction acceleration Protein enzyme digestion
Sample Volume	N/A	1 µl - 10ml	100 µl - 10 ml	<10 µl (for 1536 well) <50 µl (for 384 well) <100 µl (for 96 well)
Sample Mass	For TT1 Tube: <1,000mg For TT2 Tube: <5,000mg	<1,000 mg	<1,000 mg	<25mg for 96 well (depends on tissue and cell type)
Datasheet	CryoPrep and Tissue tube datasheets	S1 and S2 datasheets	E110 and E210 datasheets	L-series datasheet
Models**	CP02	S1 S2 S2x	E110 E210 E210x E210R	L8
Operator's manual	CryoPrep and Tissue tube manuals Training video	S1 and S2 manuals Training video	E110 and E210 manuals	L-series operator manual