Covaris / Products & Services / Overview

PRODUCTS
	Products Overview

	S-series

	E-series

	C-series

	L-series

	CryoPrep

	Supplies

	Services

Products Overview

Product Summary

Covaris, Inc. offers a complete family of instrumentation products based on focused acoustics for advanced and high-throughput biology applications. Each product is designed to fit particular application needs and volume and mass requirements. Click on the links below for more information.

	Primary Application	Suggested Volume	Suggested Mass
S-series Learn more	RNA extraction Cell lysis Low Throughput Compound Dissolution	100-1,000 µl (S1) 1,000-10,000 µl (S2)	<100 mg (S1) <1,000 mg (S2)
E-series Learn more	DMPK / ADME tox High Throughput Compound Dissolution	100-1,000 µl (E110) 1,000-10,000 µl (E210)	<1,000 mg
C-series Learn more	High Throughput Chemistry Compound Dissolution DMPK / ADME tox	1,000-10,000 µl	<1,000 mg
L-series Learn more	Tissue homogenization (small mass) Compound Dissolution Reaction acceleration	<10 µl (for 1536 well) <50 µl (for 384 well) <100 µl (for 96 well)	<25mg for 96 well (depends on tissue/cell type)
CryoPrep™ Learn more	Cryo-Pulverization of tissue prior to AFA treatments Bone, seed, hard fibrous tissue Isolation of labile biomolecules (e.g., RNA, enzymes, complexes)	N/A	TT1 <1,000 mg TT2 < 5,000 mg

Services Summary

In addition to our acoustics instruments, Covaris also offers an extraction service for sample preparation. The power and the control of the Covaris technology are now readily accessible. Disruption of plant and animal tissues is often the first step of sample preparation. The subsequent extraction of individual biomolecules from complexes and aggregates is often an uncontrolled, inefficient process. Find out how Covaris services can help companies improve their sample preparation processes.

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About the Covaris Process

Capturing the diversity of composition in a sample is a pre-requisite for laboratories performing system-wide screening and profiling. Often this initial step is based on uncontrolled, manual processes. Up-front primary biological sample preparation with The Covaris Process eliminates operator induced variation, improves recoveries, increases efficiency, and provides standardized results.

Covaris has developed computer-controlled, focused acoustic processes based on shock wave physics to enable precise, accurate sample preparation:

Isothermal, reflux process provides high efficiency
Non-contact, closed vessel process provides safety
Standardized energy transfer ensures uniform samples

The Covaris Process produces a uniform acoustic field inside a sealed vessel. The patented process is based on a computer-controlled, focused acoustic energy technology.

Previously, acoustic energy use in biological sample preparation applications has been through low frequency sonicators, such as cell disrupters, probes, and reagent mixers. However, there are intrinsic limitations with these devices. Their energy is low frequency and not focused and, therefore, uncontrolled. Samples do not receive identical energy during the process, and often samples overheat. In addition, most processes require direct sample contact; a biohazard with highly infectious samples. The non-contact Covaris Process harnesses acoustic power while providing the control required for analytical-grade sample preparation.

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