Overview
The Covaris S-series are advanced instruments based on technologies developed from both medical diagnostic imaging and therapeutic ultrasound industries. Covaris has developed numerous applications for the biological laboratory; using our S-series products, many processes can be completed within seconds.
Benefits include:
- Cost effective. Higher precision allows fewer repeats, and fewer replicate samples
- Safe. Non-contact, sealed vessel process is ideal for highly infectious and/or small sample processing
- Versatile. Disruption, extraction and dissolution may be improved
What They Do
The scalable energy of the S-series systems processes various volumes and masses in seconds. Sample integrity is maintained as the Covaris process is non-contact (for example, no evaporation or probe contact) and non-ionizing. As the process occurs in a closed vessel, there is no cross-talk between samples. Additionally, closed tube processing allows head-space modification, such as a biochemically inert gas for labile molecules. Isothermal, reflux processes from 4ºC to 40ºC are standard.
The standard S-series configuration uses a borosilicate culture tube with polypropylene screw-top closure. Additionally, the process enables tubes to have surface modifications for special applications (e.g., parylene or silane coating).
Although sample preparation requirements are diverse, for most samples, the following ranges apply:
| |
Volume |
Mass |
Tube |
|
Model S1
|
100-1,000 µl
|
<100 mg
|
13x100mm
| |
Model S2
|
1,000-10,000 µl
|
<1,000 mg
|
16x100mm
|
Upon request, the systems may be configured for other tubes and vials, temperatures and robotic systems.
| Application Areas |
Covaris Process Features |
- Tissue disruption for RNA and protein targets
- Sample extraction for metabolic profiling
- Chemical dissolution for reaction control and screening
|
- Non-contact (no cross-talk, no probe to clean)
- Rapid, scalable energy (quickly stabilize target molecules)
- Isothermal (no hot spots typically seen with "sonicator" systems)
- Multiple solvents (aqueous, organic)
|
Our proprietary software, SonoLab™, runs on Windows® XP with easy-to-use-tools. The system may also be configured for ActiveX control.
The bench-top size system is approximately 21 cm wide, 31 cm high and 52 cm deep. The unit includes a notebook computer and, if required, a chiller may be readily attached.
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